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Article

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in atrophic AMD

2023-08-09

Abstract excerpt

<h4>Introductory paragraph</h4> Age-related macular degeneration (AMD), the leading cause of geriatric blindness, is a multi-factorial disease with retinal-pigmented epithelial (RPE) cell dysfunction as a central pathogenic driver. With RPE degeneration, lysosomal function is a core process that is disrupted. Transcription factors EB/E3 (TFEB/E3) tightly control lysosomal function; their disruption can cause agin...

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Literature Corpus work
1d693e10-a1d4-5256-bed9-f10a070ee6ae
DOI
10.1101/2023.08.08.552343
Open publication

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The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in atrophic AMDDOI 10.1101/2023.08.08.552343
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