Article

Histone H3.3 Hira chaperone complex contributes to zygote formation in mice and humans

2020-06-19

Abstract excerpt

Elucidating the underlining mechanisms underpinning successful fertilisation is imperative in optimising IVF treatments, and may lead to a specific diagnosis and therefore potential treatment for some infertile couples. One of the critical steps involves paternal chromatin reprogramming, in which compacted sperm chromatin packed by protamines is removed by oocyte factors and new histones, including histone H3.3, a...

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Literature Corpus work: a9b1874b-9dd8-585a-a0bc-8d2c5c0541d2
DOI: 10.1101/2020.06.18.159954

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