Article
Asymmetry in histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote.
Mechanisms of development - 1 Sept 2005
van der Heijden Godfried W, Dieker Jürgen W, Derijck Alwin A H A, Muller Sylviane, Berden Jo H M, Braat Didi D M, van der Vlag Johan, de Boer Peter
Abstract excerpt
In mammalian fertilization, the paternal genome is delivered to the secondary oocyte by sperm with protamine compacted DNA, while the maternal genome is arrested in meiotic metaphase II. Thus, at the beginning of fertilization, the two gametic chromatin sets are strikingly different. We elaborate on this contrast by reporting asymmetry for histone H3 type in the pre-S-phase zygote when male chromatin is virtually...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.