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Article

The histone H3.3 chaperone HIRA is essential for chromatin assembly in the male pronucleus.

Nature - 27 Oct 2005

Loppin Benjamin, Bonnefoy Emilie, Anselme Caroline, Laurençon Anne, Karr Timothy L, Couble Pierre

Abstract excerpt

In sexually reproducing animals, a crucial step in zygote formation is the decondensation of the fertilizing sperm nucleus into a DNA replication-competent male pronucleus. Genome-wide nucleosome assembly on paternal DNA implies the replacement of sperm chromosomal proteins, such as protamines, by maternally provided histones. This fundamental process is specifically impaired in sésame (ssm), a unique Drosophila...

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Share to Chromatin
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16251970
DOI: 10.1038/nature04059

Genes

HIRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The histone H3.3 chaperone HIRA is essential for chromatin assembly in the male pronucleus.PMID 16251970Read ↗

The essential role of Drosophila HIRA for de novo assembly of paternal chromatin at fertilization.Semantic proximity Read ↗

Histone H3.3 Hira chaperone complex contributes to zygote formation in mice and humansSemantic proximity Read ↗

Asymmetry in histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote.Semantic proximity Read ↗

HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype.Semantic proximity Read ↗

The Drosophila maternal gene sésame is required for sperm chromatin remodeling at fertilization.Semantic proximity Read ↗

Histone removal in sperm protects paternal chromosomes from premature division at fertilizationSemantic proximity Read ↗

Histone variants: essential actors in male genome programming.Semantic proximity Read ↗

A developmental requirement for HIRA-dependent H3.3 deposition revealed at gastrulation in Xenopus.Semantic proximity Read ↗

Transcriptional and developmental functions of the H3.3 histone variant in Drosophila.Semantic proximity Read ↗

Histone Variants: The Nexus of Developmental Decisions and Epigenetic Memory.Semantic proximity Read ↗

The double face of the histone variant H3.3.Semantic proximity Read ↗

Sperm-derived histones contribute to zygotic chromatin in humansSemantic proximity Read ↗

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