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Article

Biparental contributions of the H2A.B histone variant control embryonic development in mice.

PLoS biology - 1 Dec 2020

Molaro Antoine, Wood Anna J, Janssens Derek, Kindelay Selina M, Eickbush Michael T, Wu Steven, Singh Priti, Muller Charles H, Henikoff Steven, Malik Harmit S

Abstract excerpt

Histone variants expand chromatin functions in eukaryote genomes. H2A.B genes are testis-expressed short histone H2A variants that arose in placental mammals. Their biological functions remain largely unknown. To investigate their function, we generated a knockout (KO) model that disrupts all 3 H2A.B genes in mice. We show that H2A.B KO males have globally altered chromatin structure in postmeiotic germ cells....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33362208
DOI: 10.1371/journal.pbio.3001001
PMCID: PMC7757805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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