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Article

The essential role of Drosophila HIRA for de novo assembly of paternal chromatin at fertilization.

PLoS genetics - 1 Oct 2007

Bonnefoy Emilie, Orsi Guillermo A, Couble Pierre, Loppin Benjamin

Abstract excerpt

In many animal species, the sperm DNA is packaged with male germ line--specific chromosomal proteins, including protamines. At fertilization, these non-histone proteins are removed from the decondensing sperm nucleus and replaced with maternally provided histones to form the DNA replication competent male pronucleus. By studying a point mutant allele of the Drosophila Hira gene, we previously showed that HIRA, a...

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Identifiers

PMID: 17967064
DOI: 10.1371/journal.pgen.0030182
PMCID: PMC2041997

Genes

HIRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The essential role of Drosophila HIRA for de novo assembly of paternal chromatin at fertilization.PMID 17967064Read ↗

The histone H3.3 chaperone HIRA is essential for chromatin assembly in the male pronucleus.Semantic proximity Read ↗

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HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype.Semantic proximity Read ↗

Transcriptional and developmental functions of the H3.3 histone variant in Drosophila.Semantic proximity Read ↗

Histone removal in sperm protects paternal chromosomes from premature division at fertilizationSemantic proximity Read ↗

A developmental requirement for HIRA-dependent H3.3 deposition revealed at gastrulation in Xenopus.Semantic proximity Read ↗

Replication-independent histone deposition by the HIR complex and Asf1.Semantic proximity Read ↗

Asymmetry in histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote.Semantic proximity Read ↗

The CAF-1 and Hir Histone Chaperones Associate with Sites of Meiotic Double-Strand Breaks in Budding Yeast.Semantic proximity Read ↗

The histone chaperone complex HIR maintains nucleosome occupancy and counterbalances impaired histone deposition in CAF-1 complex mutants.Semantic proximity Read ↗

CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivo.Semantic proximity Read ↗

Replacement by Drosophila melanogaster protamines and Mst77F of histones during chromatin condensation in late spermatids and role of sesame in the removal of these proteins from the male pronucleus.Semantic proximity Read ↗

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