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Article

HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype.

Reproduction (Cambridge, England) - 10 May 2021

Smith Rowena, Pickering Sue J, Kopakaki Anna, Thong K J, Anderson Richard A, Lin Chih-Jen

Abstract excerpt

Elucidating the mechanisms underpinning fertilisation is essential to optimising IVF procedures. One of the critical steps involves paternal chromatin reprogramming, in which compacted sperm chromatin packed by protamines is removed by oocyte factors and new histones, including histone H3.3, are incorporated. HIRA is the main H3.3 chaperone governing this protamine-to-histone exchange. Failure of this step...

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Identifiers

PMID: 33835048
DOI: 10.1530/REP-20-0636
PMCID: PMC8188263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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