Article

FAK drives resistance to therapy in HPV-negative head and neck cancer in a p53-dependent manner

2022-06-03

Abstract excerpt

Radiation and platinum-based chemotherapy form the backbone of therapy in HPV-negative head and neck squamous cell carcinoma (HNSCC). We have correlated focal adhesion kinase (FAK/ PTK2 ) expression with radioresistance and worse outcome in these patients. However, the importance of FAK in driving radioresistance and its effects on chemoresistance in these patients remain unclear. We performed an in vivo shRNA s...

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Literature Corpus work: a989b220-6916-5626-bd3d-807b953327ba
DOI: 10.1101/2022.06.03.494547

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