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Article

Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth.

BMC cancer - 11 Jul 2013

Golubovskaya Vita M, Ho Baotran, Zheng Min, Magis Andrew, Ostrov David, Morrison Carl, Cance William G

Abstract excerpt

BACKGROUND: Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor kinase that plays a major role in cancer cell survival and metastasis. METHODS: We performed computer modeling of the p53 peptide containing the site of interaction with FAK, predicted the peptide structure and docked it into the three-dimensional structure of the N-terminal domain of FAK involved in the complex with p53. We screened small molecule...

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Source

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Identifiers

PMID: 23841915
DOI: 10.1186/1471-2407-13-342
PMCID: PMC3712010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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