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Article

Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome.

Molecular cancer - 21 Feb 2024

Broghammer Felix, Korovina Irina, Gouda Mahesh, Celotti Martina, van Es Johan, Lange Inga, Brunner Cornelia, Mircetic Jovan, Coppes Robert P, Gires Olivier, Dahl Andreas, Seifert Michael, Cordes Nils

Abstract excerpt

BACKGROUND: Focal adhesion signaling involving receptor tyrosine kinases (RTK) and integrins co-controls cancer cell survival and therapy resistance. However, co-dependencies between these receptors and therapeutically exploitable vulnerabilities remain largely elusive in HPV-negative head and neck squamous cell carcinoma (HNSCC). METHODS: The cytotoxic and radiochemosensitizing potential of targeting 10 RTK and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38378518
DOI: 10.1186/s12943-024-01954-8
PMCID: PMC10880239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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