Article

Loss of endothelial cell FAK represses cisplatin-induced vascular senescence in distal niches to reduce lung metastatic burden

2026-08-25

Abstract excerpt

<title>Abstract</title> <p>Platinum-based chemotherapy is widely used to treat non-small cell lung cancer: however, intrathoracic metastasis remains a major clinical challenge associated with increased morbidity. While chemotherapy is generally viewed as acting directly on tumour cells, it can also reprogramme the tumour microenvironment, including vascular endothelial cells. Here, we identify endothelial cell fo...

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Literature Corpus work: 4c12113b-168a-509a-b3cd-1a2c17934072
DOI: 10.21203/rs.3.rs-10046163/v1

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