Article

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

2019-03-30

Abstract excerpt

Gene copy number changes, cancer stem cell (CSC) increases, and platinum chemotherapy resistance contribute to poor prognosis in patients with recurrent high grade serous ovarian cancer (HGSOC). CSC phenotypes involving Wnt-β-catenin and aldehyde dehydrogenase activities, platinum resistance, and tumor initiating frequency are here associated with spontaneous genetic gains, including genes encoding K RAS , M YC...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d1aa7e68-ee86-53d4-9800-547c6d02a6eb
DOI: 10.1101/594184

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapyDOI 10.1101/594184Read

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapySemantic proximity Read

Integrin-linked kinase-frizzled 7 interaction maintains cancer stem cells to drive platinum resistance in ovarian cancerSemantic proximity Read

The MEK1/2 pathway as a therapeutic target in high-grade serous ovarian carcinomaSemantic proximity Read

Integrin-linked kinase-frizzled 7 interaction maintains cancer stem cells to drive platinum resistance in ovarian cancerSemantic proximity Read

Integrated analysis of scRNA-seq and bulk RNA-seq identifies FBXO2 as a candidate biomarker associated with chemoresistance in HGSOCSemantic proximity Read

Co-targeting the PI3K-Akt pathway improves response to MEK inhibition in low-grade serous ovarian cancer cell linesSemantic proximity Read

Single-cell analysis of a high-grade serous ovarian cancer cell line reveals transcriptomic changes and cell subpopulations sensitive to epigenetic combination treatmentSemantic proximity Read

FAK signaling in human cancer as a target for therapeuticsSemantic proximity Read

Anaplastic carcinoma of the ovary: A single-institution experience and molecular analysis.Semantic proximity Read

Genomic evolution and chemoresistance in germ-cell tumours.Semantic proximity Read

Cancer associated fibroblasts serve as an ovarian cancer stem cell niche through noncanonical Wnt5a signalingSemantic proximity Read

Exploiting a living biobank to delineate mechanisms underlying disease-specific chromosome instabilitySemantic proximity Read