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Article

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

2 Sept 2019

Abstract excerpt

Gene copy number alterations, tumor cell stemness, and the development of platinum chemotherapy resistance contribute to high-grade serous ovarian cancer (HGSOC) recurrence. Stem phenotypes involving Wnt-β-catenin, aldehyde dehydrogenase activities, intrinsic platinum resistance, and tumorsphere formation are here associated with spontaneous gains in Kras, Myc and FAK (KMF) genes in a new aggressive murine model...

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PMID: 31478830
DOI: 10.7554/elife.47327

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