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Article

Focal Adhesion Kinase Regulates the DNA Damage Response and Its Inhibition Radiosensitizes Mutant KRAS Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2016

Tang Ke-Jing, Constanzo Jerfiz D, Venkateswaran Niranjan, Melegari Margherita, Ilcheva Mariya, Morales Julio C, Skoulidis Ferdinandos, Heymach John V, Boothman David A, Scaglioni Pier Paolo

Abstract excerpt

PURPOSE: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide due to the limited availability of effective therapeutic options. For instance, there are no effective strategies for NSCLCs that harbor mutant KRAS, the most commonly mutated oncogene in NSCLC. Thus, our purpose was to make progress toward the generation of a novel therapeutic strategy for NSCLC. EXPERIMENTAL...

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Source

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Identifiers

PMID: 27220963
DOI: 10.1158/1078-0432.CCR-15-2603
PMCID: PMC5122471

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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