Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drug-Sensitivity Screening and Genomic Characterization of 45 HPV-Negative Head and Neck Carcinoma Cell Lines for Novel Biomarkers of Drug Efficacy

3 Jul 2018

Abstract excerpt

Abstract There is an unmet need for effective targeted therapies for patients with advanced head and neck squamous cell carcinoma (HNSCC). We correlated gene expression, gene copy numbers, and point mutations in 45 human papillomavirus–negative HNSCC cell lines with the sensitivity to 220 anticancer drugs to discover predictive associations to genetic alterations. The drug response profiles revealed diverse...

Topics

Join the communities discussing this publication.

Head and Neck Cancer Studies
Lung Cancer Treatments and Mutations
Plant Disease Resistance and Genetics

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29970484
DOI: 10.1158/1535-7163.mct-17-0733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drug-Sensitivity Screening and Genomic Characterization of 45 HPV-Negative Head and Neck Carcinoma Cell Lines for Novel Biomarkers of Drug EfficacyPMID 29970484Read ↗

Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer.Semantic proximity Read ↗

Genomic analysis of head and neck squamous cell carcinoma cell lines and human tumors: a rational approach to preclinical model selection.Semantic proximity Read ↗

The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapiesSemantic proximity Read ↗

Exploiting high-throughput cell line drug screening studies to identify candidate therapeutic agents in head and neck cancer.Semantic proximity Read ↗

Genotyping and Characterization of HPV Status, Hypoxia, and Radiosensitivity in 22 Head and Neck Cancer Cell LinesSemantic proximity Read ↗

Molecular profiling of head and neck squamous cell carcinoma.Semantic proximity Read ↗

Molecular landscape of head and neck cancer and implications for therapySemantic proximity Read ↗

Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas.Semantic proximity Read ↗

Investigating the Feasibility of Targeted Next-Generation Sequencing to Guide the Treatment of Head and Neck Squamous Cell Carcinoma.Semantic proximity Read ↗

Sequencing the head and neck cancer genome: implications for therapy.Semantic proximity Read ↗

Leveraging Genomics for Head and Neck Cancer Treatment.Semantic proximity Read ↗

Targeted next-generation sequencing of locally advanced squamous cell carcinomas of the head and neck reveals druggable targets for improving adjuvant chemoradiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.