Article
Translational products encoded by novel ORFs may form protein-like structures and have biological functions
2019-03-05
Abstract excerpt
Translation products encoded by non canonical or novel open reading frame (ORF) genomic regions are generally considered too small to play any significant biological role, and dismissed as inconsequential. In this study, we show that mutations mapping to novel ORFs have significantly higher pathogenicity scores than mutations in protein-coding regions. Importantly, novel ORFs can translate into protein-like struct...
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Identifiers and source
- Literature Corpus work
- a964bb29-3a29-5335-aec2-5f3579179b32
- DOI
- 10.1101/567800