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Article

Enhancing the annotation of small ORF-altering variants using MORFEE: introducing MORFEEdb, a comprehensive catalog of SNVs affecting upstream ORFs in human 5'UTRs.

NAR genomics and bioinformatics - 1 Mar 2025

Meguerditchian Caroline, Baux David, Ludwig Thomas E, Genin Emmanuelle, Trégouët David-Alexandre, Soukarieh Omar

Abstract excerpt

Non-canonical small open reading frames (sORFs) are among the main regulators of gene expression. The most studied of these are upstream ORFs (upORFs) located in the 5'-untranslated region (UTR) of coding genes. Internal ORFs (intORFs) in the coding sequence and downstream ORFs (dORFs) in the 3'UTR have received less attention. Different bioinformatics tools permit the prediction of single nucleotide variants...

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Topics

Humans
Open Reading Frames
5' Untranslated Regions
Polymorphism, Single Nucleotide
Software

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Molecular Sequence Annotation

Computational Biology

Source

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Identifiers

PMID: 40109352
DOI: 10.1093/nargab/lqaf017
PMCID: PMC11920869

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