Article

Proteins encoded by Novel ORFs have increased disorder but can be biochemically regulated and harbour pathogenic mutations

2019-02-27

Abstract excerpt

Recent evidence has suggested that protein or protein-like products can be encoded by previously uncharacterized Open Reading Frames (ORFs) that we define as Novel Open Reading Frames (nORFs) 1,2 . These nORFs are present in both coding and non coding regions of the human genome and the novel proteins that they encode have increased the number and complexity of cellular proteome from bacteria to humans. It is a c...

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Literature Corpus work: 0e25b50b-ce7f-5143-8399-69dff1cee65e
DOI: 10.1101/562835

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