Article
Re-recognition of pseudogenes: From molecular to clinical applications.
Theranostics - 1 Jan 2020
Chen Xu, Wan Lin, Wang Wei, Xi Wen-Jin, Yang An-Gang, Wang Tao
Abstract excerpt
Pseudogenes were initially regarded as "nonfunctional" genomic elements that did not have protein-coding abilities due to several endogenous inactivating mutations. Although pseudogenes are widely expressed in prokaryotes and eukaryotes, for decades, they have been largely ignored and classified as gene "junk" or "relics". With the widespread availability of high-throughput sequencing analysis, especially omics...
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