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Article

Open reading frames associated with cancer in the dark matter of the human genome.

Cancer genomics & proteomics - 1 Jan 2000

Delgado Ana Paula, Brandao Pamela, Chapado Maria Julia, Hamid Sheilin, Narayanan Ramaswamy

Abstract excerpt

BACKGROUND: The uncharacterized proteins (open reading frames, ORFs) in the human genome offer an opportunity to discover novel targets for cancer. A systematic analysis of the dark matter of the human proteome for druggability and biomarker discovery is crucial to mining the genome. Numerous data mining tools are available to mine these ORFs to develop a comprehensive knowledge base for future target discovery...

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PMID: 25048349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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