Article

Enhancing the annotation of small ORF-altering variants using MORFEE: introducing MORFEEdb, a comprehensive catalog of SNVs affecting upstream ORFs in human 5’UTRs

2024-10-10

Abstract excerpt

Non-canonical small Open Reading Frames (sORFs) are among main regulators of gene expression. The most studied ones are upstream ORFs (upORFs) located in the 5’UTR of coding genes. Internal ORFs (intORFs) in the coding sequence and downstream ORFs (dORFs) in the 3’UTR have received less attention. Different bioinformatics tools permit to predict single nucleotide variants (SNVs) altering upORFs, mainly those creat...

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Literature Corpus work: bd36c9fc-2acc-5ac3-85fa-deac29d6c40d
DOI: 10.1101/2024.10.07.616631

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