Article

APP overexpression delays synaptic development and alters neuronal network properties

2025-03-13

Abstract excerpt

The amyloid precursor protein (APP) regulates neuronal excitability by altering the structure of the axon initial segment. Using high density multielectrode arrays we compared the electrophysiological consequences of APP overexpression with exposure to β-amyloid (Aβ) and found that the two manipulations affected neural activity in largely non-overlapping ways. In mature cultures (>18 days in vitro, DIV18), APP red...

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Identifiers and source

Literature Corpus work: 923948ae-52ad-53ce-996d-2b74d90177b3
DOI: 10.1101/2025.03.12.641184

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