Article

Immortalization of human zone I hepatocytes from biliary atresia with CDK4 <sup>R24C</sup> , cyclin D1, and TERT for cytochrome P450 induction testing

2019-08-08

Abstract excerpt

<h4>Background</h4> Hepatocytes are an important tool for in vitro toxicology testing. In addition to primary cultures, a limited number of immortalized cell lines have been developed. We here describe a new cell line, designated as HepaMN, which has been established from a liver associated with biliary atresia. <h4>Methods</h4> Hepatocytes were isolated from a liver of 4-year-old girl with biliary atresia and i...

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Literature Corpus work: a9458bbd-0da6-53ee-8adf-12786ceb4a38
DOI: 10.1101/729525

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