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Article

Immortalization of human hepatocytes from biliary atresia with CDK4R24C, cyclin D1, and TERT for cytochrome P450 induction testing.

Scientific reports - 15 Oct 2020

Nishiwaki Manami, Toyoda Masashi, Oishi Yoshie, Ishida Seiichi, Horiuchi Shin-Ichiro, Makino-Itou Hatsune, Kimura Tohru, Ohno Shin-Ichi, Ohkura Takashi, Enosawa Shin, Akutsu Hidenori, Nakazawa Atsuko, Kasahara Mureo, Kiyono Tohru, Umezawa Akihiro

Abstract excerpt

Hepatocytes are an important tool for in vitro toxicology testing. In addition to primary cultures, a limited number of immortalized cell lines have been developed. We here describe a new cell line, designated as HepaMN, which has been established from a liver associated with biliary atresia. Hepatocytes were isolated from a liver of 4-year-old girl with biliary atresia and immortalized by inoculation with...

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Identifiers

PMID: 33060611
DOI: 10.1038/s41598-020-73992-3
PMCID: PMC7567112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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