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Puromycin selection of cells with a high expression of the cytochrome P450 CYP3A4 gene activity from a patient with drug-induced liver injury (DILI) and their lifespan prolongation using a combination of CDK4 <sup>R24C</sup> , cyclin D1 and TERT

2020-04-25

Abstract excerpt

<h4>ABSTRACT</h4> Many drugs have the potential to induce the expression of drug-metabolizing enzymes, particularly cytochrome P450 3A4 (CYP3A4), in hepatocytes. Hepatocytes can accurately evaluate drug-mediated CYP3A4 induction as the gold standard for in vitro hepatic toxicology test, but their lot variation is an issue to be solved. Only a limited number of immortalized hepatocyte cells have been reported. In...

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Literature Corpus work
68ebf0fb-1e4d-5ecd-9180-62f9f19ee20b
DOI
10.1101/2020.04.25.061275
Open publication

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