Article

Development of optimised human iPSC-derived hepatocytes with improved liver function for <i>in vitro</i> metabolic disease modelling and toxicity studies

2024-11-19

Abstract excerpt

<h4>Background & Aims</h4> Liver disease is a rising cause of mortality worldwide. Primary human hepatocytes (PHH) and hepatocellular cancer cells are currently used in drug development, however, they come with limitations, including limited supply, rapid loss of function, and tumorigenic origin. In addition, current iPSC differentiation protocols lead to the generation of hepatocyte-like cells with compromised l...

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Literature Corpus work: 94eedb2e-2752-518d-b1b9-40f7ffb813c1
DOI: 10.1101/2024.11.18.624145

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