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Hepatic Cell Lines for Drug Hepatotoxicity Testing: Limitations and Strategies to Upgrade their Metabolic Competence by Gene Engineering

1 Oct 2013

Abstract excerpt

One key issue in the pharmaceutical development of new compounds is knowledge on metabolism, the enzymes involved and the potential hepatotoxicity of a drug. Primary cultured hepatocytes are a valuable in vitro model for drug metabolism studies. However, human hepatocytes show phenotypic instability and have restricted accessibility and high batch-to-batch functional variability, which seriously complicates their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24160292
DOI: 10.2174/1389200211314090002

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