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Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies

24 Mar 2006

Abstract excerpt

Gaining knowledge on the metabolism of a drug, the enzymes involved and its inhibition or induction potential is a necessary step in pharmaceutical development of new compounds. Primary human hepatocytes are considered a cellular model of reference, as they express the majority of drug-metabolising enzymes, respond to enzyme inducers and are capable of generating in vitro a metabolic profile similar to what is...

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PMID: 16866607
DOI: 10.1517/17425255.2.2.183

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