Human Hepatic Hepa<scp>RG</scp> Cells Maintain an Organotypic Phenotype with High Intrinsic <scp>CYP</scp>450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications

Abstract excerpt

Abstract Conventional in vitro human hepatic models for drug testing are based on the use of standard cell lines derived from hepatomas or primary human hepatocytes ( PHH s). Limited availability, interdonor functional variability and early phenotypic alterations in PHH s restrict their use, whilst standard cell lines such as HepG2 lack a substantial and variable set of liver‐specific functions such as CYP 450...