Article

Human biliary atresia extrahepatic cholangiocyte organoids express increased ER and oxidative stress, altered drug metabolism and cell polarity changes

2025-05-04

Abstract excerpt

<h4>Background & Aims</h4> Biliary atresia (BA), the leading cause of liver transplantation in children, presents in neonates with jaundice and progressive extrahepatic bile duct obstruction, yet its etiology and pathogenesis remain unknown. Here, we aimed to investigate the molecular mechanisms underlying BA and the susceptibility of cholangiocytes in the extrahepatic biliary tree using patient-derived extrahepa...

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Literature Corpus work: af996e63-c3a3-5483-9c16-c215f7263eb8
DOI: 10.1101/2025.05.04.649927

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