Effects of Presenilin-1 Familial Alzheimer’s Disease Mutations on γ-Secretase Activation for Cleavage of Amyloid Precursor Protein

Abstract excerpt

<title>Abstract</title> <p>γPresenilin-1 (PS1) is the catalytic subunit of γ-secretase, the “proteasome of the membrane” which cleaves within the membrane of 150 + peptide substrates. Dominant missense mutations in PS1 cause early-onset familial Alzheimer’s disease (FAD); however, the exact pathogenic mechanism remains unknown. Here we combined Gaussian-accelerated molecular dynamics (GaMD) simulations and bioche...

Topics

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• Alzheimer Disease
• Alzheimer's disease research and treatments
• Amyloid beta-Protein Precursor
• Amyloid Precursor Protein Secretases
• Computational Drug Discovery Methods
• Mutation
• Presenilin-1
• Protein Structure and Dynamics

Identifiers and source

Literature Corpus work

307930f8-5538-5899-89f6-aa8f35b77c7d

DOI

10.21203/rs.3.rs-1910553/v1