Article

3D, multi-omic imaging reveals molecular biomarkers of the pre-metastatic niche in lung cancer

2026-02-18

Abstract excerpt

The recurrence rate following complete surgical resection of primary non-small cell lung cancer is as high as 55%, yet no approach currently exists to evaluate the risk of local recurrence. The premetastatic paradigm is the recognition that metastasis is preceded by reprogramming naïve tissues to prime a microenvironment for tumor cell survival and subsequent reactivation. Identification of biomarkers of the pre-m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a92ab0af-809c-5a0e-b06e-093bf3b0f0db
DOI: 10.64898/2026.02.18.706515

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

3D, multi-omic imaging reveals molecular biomarkers of the pre-metastatic niche in lung cancerDOI 10.64898/2026.02.18.706515Read

High-resolution molecular atlas of a lung tumor in 3DSemantic proximity Read

Acquisition of discrete immune suppressive barriers contributes to the initiation and progression of preinvasive to invasive human lung cancerSemantic proximity Read

Spatial resolution of cellular senescence dynamics in human colorectal liver metastasisSemantic proximity Read

Novel Spatial Approaches to Dissect the Lung Cancer Immune MicroenvironmentSemantic proximity Read

Decoding metastatic microenvironments through single-cell omics reveals new insights into niche dynamics and tumor evolutionSemantic proximity Read

Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung CancerSemantic proximity Read

A cellular and spatial atlas of <i>TP53</i> -associated tissue remodeling in lung adenocarcinomaSemantic proximity Read

Patient-Derived Three-Dimensional Lung Tumor Models to Evaluate Response to ImmunotherapySemantic proximity Read

Multi-omics Integration Analysis Identifies MMP1, HILPDA, and COL6A5 as Critical Determinants of Invasive Progression and Metastatic Adaptation in Lung AdenocarcinomaSemantic proximity Read

Spatially Organized Tertiary Lymphoid Structures Emerge in Small Cell Lung Cancer and Associate with Improved SurvivalSemantic proximity Read

Longitudinal spatial multi-omics delineates tumor microenvironment remodeling across sequential EGFR-TKIs in EGFR-mutant NSCLCSemantic proximity Read

Spatially mapping the tumour immune microenvironments of non-small cell lung cancerSemantic proximity Read