Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of an orthotopic mouse transplant model reveals early changes in the tumor microenvironment of lung cancer.

BMB reports - 1 Nov 2024

Na Minsu, Kang Huiram, Kim Nayoung, Jo Areum, Lee Hae-Ock

Abstract excerpt

To understand the cellular and molecular dynamics in the early stages of lung cancer, we explored a mouse model of orthotopic tumor transplant created from the Lewis Lung Carcinoma (LLC) cell line. Employing single-cell RNA sequencing, we analyzed the cellular landscape during tumor engraftment, focusing particularly on LLC cells harboring the Kras G12C mutation. This allowed us to identify LLC tumor cells via...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Lung Neoplasms

Share to Mice, Inbred C57BL

Share to Proto-Oncogene Proteins p21(ras)

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 39044458
PMCID: PMC11608852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of an orthotopic mouse transplant model reveals early changes in the tumor microenvironment of lung cancer.PMID 39044458Read ↗

Transcriptome Analysis of Individual Stromal Cell Populations Identifies Stroma-Tumor Crosstalk in Mouse Lung Cancer ModelSemantic proximity Read ↗

Single-Cell Transcriptomic Analyses of Tumor Ecosystems and Spatial Architectures in Human Small Cell Lung CancerSemantic proximity Read ↗

Promising immunotherapeutic targets in lung cancer based on single-cell RNA sequencingSemantic proximity Read ↗

Modeling Molecular Pathogenesis of Idiopathic Pulmonary Fibrosis-Associated Lung Cancer in MiceSemantic proximity Read ↗

Animal models of lung cancer: Phenotypic comparison of different animal models of lung cancer and their application in the study of mechanisms.Semantic proximity Read ↗

Cross-species analysis identifies genotype-driven vulnerabilities in lung adenocarcinomaSemantic proximity Read ↗

Lung tumoroids as a testing platform for precision CAR T-cell therapySemantic proximity Read ↗

Whole‑exome sequencing reveals Lewis lung carcinoma is a hypermutated Kras/Nras-mutant cancer with extensive regional mutation clusters in its genome.Semantic proximity Read ↗

Advances in Small-Cell Lung Cancer (SCLC) Translational Research.Semantic proximity Read ↗

Novel Spatial Approaches to Dissect the Lung Cancer Immune MicroenvironmentSemantic proximity Read ↗

Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platformSemantic proximity Read ↗

Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectoriesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.