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Article

Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis

8 May 2023

Abstract excerpt

Hepatic metastasis is a clinical challenge for colorectal cancer (CRC). Senescent cancer cells accumulate in CRC favoring tumor dissemination. Whether this mechanism progresses also in metastasis is unexplored. Here, we integrated spatial transcriptomics, 3D-microscopy, and multicellular transcriptomics to study the role of cellular senescence in human colorectal liver metastasis (CRLM). We discovered two...

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PMID: 37157887
DOI: 10.1111/acel.13853

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