Article

Patient-Derived Three-Dimensional Lung Tumor Models to Evaluate Response to Immunotherapy

2025-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Novel preclinical models that better mimic the in vivo tumor microenvironment are needed for advanced understanding of tumor biology and resistance/response to therapy. Herein, we report development of a novel ex vivo patient-derived three-dimensional lung tumor model (3D-LTM), that maintains features of human extracellular matrix, cell-cell interactions, and tissue architecture to evaluate a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a69a61c0-b6b5-5d4e-82d8-789a49f1f852
DOI: 10.1101/2025.05.19.654890

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Patient-Derived Three-Dimensional Lung Tumor Models to Evaluate Response to ImmunotherapyDOI 10.1101/2025.05.19.654890Read

High-resolution molecular atlas of a lung tumor in 3DSemantic proximity Read

Lung tumoroids as a testing platform for precision CAR T-cell therapySemantic proximity Read

Combining spatial transcriptomics and ECM imaging in 3D for mapping cellular interactions in the tumor microenvironmentSemantic proximity Read

Spatially Resolved Whole-Transcriptomic and Proteomic Profiling of Lung Cancer and Its Immune Microenvironment According to PD-L1 ExpressionSemantic proximity Read

Single-Cell RNA Sequencing Reveals Tumor Microenvironment Remodeling after Neoadjuvant Immunotherapy in Non-small Cell Lung CancerSemantic proximity Read

Integrative Analysis of Checkpoint Blockade Response in Advanced Non-Small Cell Lung CancerSemantic proximity Read

In vitro models to mimic tumor endothelial cell-mediated immune cell reprogramming in lung adenocarcinomaSemantic proximity Read

Characterizing the Dynamics of the Single Cell Tumor Microenvironment and Immune Cell Subpopulations during the Progression of Lung AdenocarcinomaSemantic proximity Read

Immunotherapeutic targets in non‐small cell lung cancerSemantic proximity Read

Novel Spatial Approaches to Dissect the Lung Cancer Immune MicroenvironmentSemantic proximity Read

Biomarker exploration for immunotherapy plus chemotherapy following resistance to third-generation EGFR-TKIs in lung adenocarcinoma.Semantic proximity Read

Enhancing Immunotherapy Outcomes: Spatial Multi-Omics Models for Non-Small Cell Lung CancerSemantic proximity Read