Article

Longitudinal spatial multi-omics delineates tumor microenvironment remodeling across sequential EGFR-TKIs in EGFR-mutant NSCLC

2026-03-08

Abstract excerpt

<title>Abstract</title> <p>Background Resistance to therapy is a frequent occurrence in patients with epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) who are treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, spatial information on how the tumor microenvironment (TME) changes within the same patient from baseline to resistance to first- and then third-generation...

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Literature Corpus work: 2ad35255-3c26-5f66-920a-1660619b62ee
DOI: 10.21203/rs.3.rs-8920893/v1

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