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Multi-omics Integration Analysis Identifies MMP1, HILPDA, and COL6A5 as Critical Determinants of Invasive Progression and Metastatic Adaptation in Lung Adenocarcinoma

2026-05-08

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<title>Abstract</title> <p> <bold>Background:</bold> The molecular transition from localized in situ lesions to invasive lung adenocarcinoma (LUAD) is a critical determinant of patient prognosis. Characterizing the transcriptomic alterations during this transition is essential for identifying early diagnostic biomarkers and potential therapeutic targets. <bold>Methods:</bold> We implemented a multi-omics anal...

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Literature Corpus work: 4a6d7865-8ba0-5b55-965b-5aaefb8ccca8
DOI: 10.21203/rs.3.rs-9644970/v1

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