Article

Spatially Organized Tertiary Lymphoid Structures Emerge in Small Cell Lung Cancer and Associate with Improved Survival

2026-08-10

Abstract excerpt

Tertiary lymphoid structures (TLS) are ectopic immune aggregates associated with improved prognosis and response to immunotherapy in multiple solid tumors. However, their presence, spatial organization, and functional relevance in small cell lung cancer (SCLC), a malignancy characterized by profound immune evasion, remain poorly understood. Using imaging mass cytometry (IMC) across 320 regions of interest spanning...

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Literature Corpus work: 61dbedc3-b7ff-51ea-8f94-3ccdcc92d4ea
DOI: 10.64898/2026.08.08.743663

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