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Evaluating selection at intermediate scales within genes provides robust identification of genes under positive selection in <i>M. tuberculosis</i> clinical isolates

2025-05-12

Abstract excerpt

Multiple studies have reported genes in the M. tuberculosis (Mtb) genome that are under diversifying selection, based on genetic variants among Mtb clinical isolates. These might reflect adaptions to selection pressures associated with modern clinical treatment of TB. Many, but not all, of these genes under selection are related to drug resistance. Most of these studies have evaluated selection at the gene-level....

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Literature Corpus work
a9009c0c-4c75-5087-a333-feb9614ff317
DOI
10.1101/2025.05.07.652684
Open publication

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Evaluating selection at intermediate scales within genes provides robust identification of genes under positive selection in <i>M. tuberculosis</i> clinical isolatesDOI 10.1101/2025.05.07.652684
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