Article
Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis.
Nature genetics - 1 Oct 2013
Farhat Maha R, Shapiro B Jesse, Kieser Karen J, Sultana Razvan, Jacobson Karen R, Victor Thomas C, Warren Robin M, Streicher Elizabeth M, Calver Alistair, Sloutsky Alex, Kaur Devinder, Posey Jamie E, Plikaytis Bonnie, Oggioni Marco R, Gardy Jennifer L, Johnston James C, Rodrigues Mabel, Tang Patrick K C, Kato-Maeda Midori, Borowsky Mark L, Muddukrishna Bhavana, Kreiswirth Barry N, Kurepina Natalia, Galagan James, Gagneux Sebastien, Birren Bruce, Rubin Eric J, Lander Eric S, Sabeti Pardis C, Murray Megan
Abstract excerpt
M. tuberculosis is evolving antibiotic resistance, threatening attempts at tuberculosis epidemic control. Mechanisms of resistance, including genetic changes favored by selection in resistant isolates, are incompletely understood. Using 116 newly sequenced and 7 previously sequenced M. tuberculosis whole genomes, we identified genome-wide signatures of positive selection specific to the 47 drug-resistant strains....
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