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Article

Gene evolutionary trajectories in Mycobacterium tuberculosis reveal temporal signs of selection.

Proceedings of the National Academy of Sciences of the United States of America - 26 Apr 2022

Chiner-Oms Álvaro, López Mariana G, Moreno-Molina Miguel, Furió Victoria, Comas Iñaki

Abstract excerpt

Genetic differences between different Mycobacterium tuberculosis complex (MTBC) strains determine their ability to transmit within different host populations, their latency times, and their drug resistance profiles. Said differences usually emerge through de novo mutations and are maintained or discarded by the balance of evolutionary forces. Using a dataset of ∼5,000 strains representing global MTBC diversity,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35452305
DOI: 10.1073/pnas.2113600119
PMCID: PMC9173582

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