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Article

Detecting selection using a single genome sequence of M. tuberculosis and P. falciparum.

Nature - 29 Apr 2004

Plotkin Joshua B, Dushoff Jonathan, Fraser Hunter B

Abstract excerpt

Selective pressures on proteins are usually measured by comparing nucleotide sequences. Here we introduce a method to detect selection on the basis of a single genome sequence. We catalogue the relative strength of selection on each gene in the entire genomes of Mycobacterium tuberculosis and Plasmodium falciparum. Our analysis confirms that most antigens are under strong selection for amino-acid substitutions,...

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Identifiers

PMID: 15118727
DOI: 10.1038/nature02458

Genes

EMP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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