Article

A <i>Legionella pneumophila</i> effector impedes host gene silencing to promote virulence

2022-11-17

Abstract excerpt

RNA silencing is a gene silencing mechanism directed by small RNAs. Human miRNAs act as central regulators of host-bacteria interactions. However, it is unknown whether human pathogenic bacteria could impede RNA silencing to promote virulence. Here, we show that the Legionella pneumophila type IV-secreted effector LegK1 efficiently suppresses siRNA and miRNA activities in human cells. This effect depends on its k...

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Literature Corpus work: a8e16aef-6f86-599f-8b7f-d717f9e7c0db
DOI: 10.1101/2022.11.16.516792

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