Article

The <i>Yersinia pestis</i> effector YopM binds the human pyrin death domain to inhibit inflammasome activation and effector-triggered immunity

2026-02-25

Abstract excerpt

<h4>ABSTRACT</h4> Bacteria in the genus Yersinia use a type III secretion system to inject several effectors into host cells to disrupt multiple signaling processes. Two effectors disrupt host signaling by inactivating RhoA GTPases. Inactivation of RhoA triggers pyrin inflammasome assembly in infected phagocytes leading to a protective immune response. A third protein, YopM, is an essential virulence factor that...

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Literature Corpus work: e87ca2c3-2181-5db4-8a44-e383f5d68b67
DOI: 10.64898/2026.02.25.707193

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