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Article

Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila.

Current biology : CB - 8 Jan 2003

Wright Edward K, Goodart Sheryl A, Growney Joseph D, Hadinoto Vey, Endrizzi Matthew G, Long E Michelle, Sadigh Keyvan, Abney Andrew L, Bernstein-Hanley Isaac, Dietrich William F

Abstract excerpt

BACKGROUND: Legionella pneumophila is a gram-negative bacterial pathogen that is the cause of Legionnaires' Disease. Legionella produces disease because it can replicate inside a specialized compartment of host macrophages. Macrophages isolated from various inbred mice exhibit large differences in permissiveness for intracellular replication of Legionella. A locus affecting this host-resistance phenotype, Lgn1,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12526741
DOI: 10.1016/s0960-9822(02)01359-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila.PMID 12526741Read ↗

Natural resistance to infection with Legionella pneumophila: chromosomal localization of the Lgn1 susceptibility gene.Semantic proximity Read ↗

Macrophages from mice with the restrictive Lgn1 allele exhibit multifactorial resistance to Legionella pneumophila.Semantic proximity Read ↗

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The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation.Semantic proximity Read ↗

A hemidominant Naip5 allele in mouse strain MOLF/Ei-derived macrophages restricts Legionella pneumophila intracellular growth.Semantic proximity Read ↗

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Genetic susceptibility and caspase activation in mouse and human macrophages are distinct for Legionella longbeachae and L. pneumophila.Semantic proximity Read ↗

High-resolution genetic and physical map of the Lgn1 interval in C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesis.Semantic proximity Read ↗

Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13.Semantic proximity Read ↗

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