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Article

Multiple Legionella pneumophila effector virulence phenotypes revealed through high-throughput analysis of targeted mutant libraries.

Proceedings of the National Academy of Sciences of the United States of America - 28 Nov 2017

Shames Stephanie R, Liu Luying, Havey James C, Schofield Whitman B, Goodman Andrew L, Roy Craig R

Abstract excerpt

Legionella pneumophila is the causative agent of a severe pneumonia called Legionnaires' disease. A single strain of L. pneumophila encodes a repertoire of over 300 different effector proteins that are delivered into host cells by the Dot/Icm type IV secretion system during infection. The large number of L. pneumophila effectors has been a limiting factor in assessing the importance of individual effectors for...

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Share to Gene Expression Regulation, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29133401
DOI: 10.1073/pnas.1708553114
PMCID: PMC5715750

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