Article

Rapamycin Rescues APC-Mutated Colon Organoid Differentiation

2024-12-17

Abstract excerpt

<title>Abstract</title> <p>Familial adenomatous polyposis (FAP) is an autosomal dominant disorder characterized by germline mutations in the adenomatous polyposis coli (APC) gene. This leads to numerous colorectal adenomas and a high risk of colorectal cancer (CRC). Our stem cell-derived colon organoid model revealed that a heterozygous APC mutation is sufficient to induce colorectal cancer formation. We found a...

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Literature Corpus work: a8dec8a7-a47b-585e-80b1-5f4322b664a9
DOI: 10.21203/rs.3.rs-5407981/v1

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