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Article

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.

Nature medicine - 1 Jul 2017

Crespo Miguel, Vilar Eduardo, Tsai Su-Yi, Chang Kyle, Amin Sadaf, Srinivasan Tara, Zhang Tuo, Pipalia Nina H, Chen Huanhuan Joyce, Witherspoon Mavee, Gordillo Miriam, Xiang Jenny Zhaoying, Maxfield Frederick R, Lipkin Steven, Evans Todd, Chen Shuibing

Abstract excerpt

With the goal of modeling human disease of the large intestine, we sought to develop an effective protocol for deriving colonic organoids (COs) from differentiated human embryonic stem cells (hESCs) or induced pluripotent stem cells (iPSCs). Extensive gene and immunohistochemical profiling confirmed that the derived COs represent colon rather than small intestine, containing stem cells, transit-amplifying cells,...

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Share to Adenomatous Polyposis Coli Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28628110
DOI: 10.1038/nm.4355
PMCID: PMC6055224

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