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Article

Shortcuts to intestinal carcinogenesis by genetic engineering in organoids

14 Jan 2019

Abstract excerpt

Inactivation of the Adenomatous polyposis coli (APC) gene is an initiating and the most relevant event in most sporadic cases of colorectal cancer, providing a rationale for using Apc-mutant mice as the disease model. Whereas carcinogenesis has been observed only at the organism level, the recent development of the organoid culture technique has enabled long-term propagation of intestinal stem cells in a...

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PMID: 30637899
DOI: 10.1111/cas.13938

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