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Article

Heterozygous APC germline mutations impart predisposition to colorectal cancer.

Scientific reports - 4 Mar 2021

Preisler Livia, Habib Aline, Shapira Guy, Kuznitsov-Yanovsky Liron, Mayshar Yoav, Carmel-Gross Ilana, Malcov Mira, Azem Foad, Shomron Noam, Kariv Revital, Hershkovitz Dov, Ben-Yosef Dalit

Abstract excerpt

Familial adenomatous polyposis (FAP) is an inherited syndrome caused by a heterozygous adenomatous polyposis coli (APC) germline mutation, associated with a profound lifetime risk for colorectal cancer. While it is well accepted that tumorigenic transformation is initiated following acquisition of a second mutation and loss of function of the APC gene, the role of heterozygous APC mutation in this process is yet...

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Share to Adenomatous Polyposis Coli
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33664379
DOI: 10.1038/s41598-021-84564-4
PMCID: PMC7933349

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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